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Chukhajian E, Speaker at Catalysis Conference
The Scientific Technological Centre of Organic and Pharmaceutical Chemistry of National Academy of Sciences,, Armenia
Title : Base catalized intramolecular Cyclization of allyl(3 (4 bromphenyl)prop-2 ynyl)ammonium bromides and water base cleavage reaction of obtained cyclic products


It was established that for Cyclization of salts 1 a-e in the presence of base in mole ratio salt/base 5/1,  in contrast to propargylic analogs [1,2], need to be  heating reaction mixture at 90 0C for 2 h. In these conditions along with Cyclization, which is the main direction, take place also rearrangement-cleavage reaction leading to formation of corresponding secondary amines and 1-allylcinnamaldehyde. It is shown that cyclic products 2 a-e rather smoothly undergo water-base cleavage reaction in the directions of 1,2 and 1,6. In the results were formed the mixture of isomer amines 3 a,b,d,e and 4 a,b,d,e with 57-60 % overall yields. According to NMR H1 and C13 the mixture is composed of the two isomer amines with different percentage ratio. 


Prof.  Emma Chukhajian is Leading Scientist and Head of the laboratory of aminocompounds of The Scientific Technological Centre of Organic and Pharmaceutical Chemistry of National Academy of Sciences of Republic of Armenia. She obtained her Ph.D. in Science in 1970 and postdoctorial in the group of Academician Araksya T. Babayan. In 1969 with A. Babayan she discovered base-catalized intramolecular Cyclization of unsaturated ammonium salts containing β,ϒ-unsaturated groups along with 3-alkenyl(aryl)propargylic groups. In 2003 she with coauthors revealed intramolecular Recyclization of 4-hydroxymethylisoindolinium salts and their condensed derivatives. Among of cyclic products there are representatives with pharmacological activity. In 2008 – the phenomenon of isomerisation of 3a,4-dihydroisoindolinium salts, in 2011 – that Stevens rearrangement of the salts, containing allylic type group along with 4-hydroxybuth-2-ynyl, includes the stages of simultaneously transfer of reaction centre in accepting group and conversion of migrating group, in 2016 – phenomenon of deamination during vacuum distillation of 3-(dialkylamino)-1,4-diarylhex-5-en-1-yns and was worked out the method of preparation of terphenyle and its derivatives.