Title : Synthesis and characterization of isonicotinic acid and nicotinic acid metal organic frameworks for use in the treatment of hepatocellular carcinoma
Abstract:
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, with its incidence steadily rising due to factors such as hepatitis infections and chronic liver disease (Alawyia and Constantinou 2023). Recent advancements in drug delivery systems present promising avenues for targeted therapies and enhanced treatment efficacy (Khizar et al. 2023). Metal-Organic Frameworks (MOFs) have emerged as effective platforms for anticancer therapies, functioning as carriers for drug delivery owing to their tunable porosity, high surface area, and biocompatibility(Feng et al. 2022).
This study focuses on the synthesis of MOFs using isonicotinic acid (INA) and nicotinic acid (NA) as organic linkers, with cobalt (Co), nickel (Ni), manganese (Mn), zinc (Zn), and copper (Cu) serving as metal centers. The solvothermal method was employed for MOF synthesis. Characterization was conducted through powder X-ray diffraction (P-XRD) to confirm crystallinity and Fourier-transform infrared spectroscopy (FTIR) to verify functional group coordination. Single-crystal X-ray diffraction (SC-XRD) was utilized to elucidate the crystal structures, while Brunauer–Emmett–Teller (BET) analysis will be performed to assess surface area and porosity, critical for evaluating drug loading and release capacities.
Preliminary results indicate that all synthesized MOFs exhibit high crystallinity and thermal stability. Structural analysis revealed that the Zn-INA MOF crystallizes in a hexagonal system, whereas the Co-INA MOF adopts a triclinic system. Porosity estimated from SC-XRD data will be corroborated through BET analysis.
This study highlights the potential of MOFs in advancing cancer therapeutics and lays the foundation for future investigations into their biomedical applications
