Title : Catalytic esterification for the efficient synthesis of phosphinic dipeptides and their acetylated glucose derivatives
Abstract:
The successful synthesis of novel phosphinic dipeptides and their acetylated glucose derivatives via an efficient esterification process is reported. Reaction of phosphinic dipeptides with 1,2,3,4-tetra-O-acetyl-β-D-glucopyranose (TGA) afforded carbohydrate-based phosphinic esters in high yield. This streamlined methodology simplifies the production process while providing a versatile platform for further structural modifications. The smooth synthesis of both the dipeptide and TGA-derived ester frameworks lays the foundation for the development of well-known phosphinic protease inhibitors and their corresponding sugar conjugates. The presentation details the synthetic strategies employed, the optimized reaction conditions, and the potential impact of these compounds in drug design.