Chiral resolution, also known as enantiomeric resolution, is a stereochemical technique that separates racemic substances into their enantiomers. It is a critical tool in the manufacture of optically active molecules, including medicines. Optical resolution is another phrase for the same thing. The downside of using chiral resolution to generate enantiomerically pure molecules is that at least half of the beginning racemic mixture must be discarded. One method of eliminating this waste is asymmetric synthesis of one of the enantiomers. The most typical approach for chiral resolution includes reacting the racemic mixture with chiral derivatizing agents, also known as chiral resolving agents, to produce a pair of diastereomeric derivatives. The derivatives are then separated by conventional crystallisation and converted back to the enantiomers when the resolving agent is removed. The method can be time-consuming and is dependent on the diastereomers' differential solubilities, which are difficult to anticipate. The less soluble diastereomer is frequently targeted, while the other is discarded or racemized for reuse. It is typical practise to test several resolving agents. A typical derivatization reaction includes the production of a salt between an amine and a carboxylic acid. The pure enantiomer is then obtained by simple deprotonation. Tartaric acid and the amine brucine are examples of chiral derivatizing agents. Louis Pasteur (again) established the technique in 1853 by resolving racemic tartaric acid with optically active (+)-cinchotoxine.
Title : Distant binuclear vanadium V(II) cationic sites in zeolites and their reactivity
Jiri Dedecek, J Heyrovsky Institute of Physical Chemistry , Czech Republic
Title : Oxidation of methane to methanol over pairs of transition metal ions stabilized in the zeolite matrices
Jiri Dedecek, J Heyrovsky Institute of Physical Chemistry , Czech Republic
Title : The Concept and Implications of Low Carbon Green Growth
Dai Yeun Jeong, Asia Climate Change Education Center, Korea, Republic of
Title : Memory characteristics and diffusionless phase transformations in shape memory alloys
Osman Adiguzel, Firat University, Turkey
Title : The Fe PNP 15 H2O catalyst reduction catalytic test and its valorisation as acid catalyst to the methylal synthesis
Rabeharitsara Andry Tahina, GPCI-ESPA Antananarivo University, Madagascar