Single-site catalysts (SSCs), a new class of catalysts, exhibit extraordinary catalytic activity and selectivity due to the unsaturated coordination configuration of active centres, the quantum size effect, and the support effect, which bridges the gap between homogeneous and heterogeneous Catalysis. The most optimal use of precious metals is shown by the SSCs, which are extremely appealing. To present, the SSCs have demonstrated outstanding catalytic activity in various significant processes, including oxidation/hydrogenation reaction, water-gas shift, and electrocatalysis3,5. The majority of synthetic techniques need specialised equipment, difficult processes, or expensive precursors, and SSCs typically aggregate during the catalytic process. Metal-support interactions are a fundamental factor in SSC investigations because they have a significant impact on the formation and catalytic durability of SSCs.