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Ligand Effects

Changing the concentrations of ligands—non-scaffold molecules that bind to particular sites on scaffolds—can control the phase transitions of scaffolds. The valence of ligands, whether or not they bind to spacers or stickers directly, and the relative affinities of ligand-scaffold versus scaffold-scaffold interactions all affect how modulatory an effect they have. The concentration of scaffolds in condensates is generally diluted by all ligands. Multivalent ligands have the ability to stabilise or destabilise condensates by directly binding to spacers or stickers, as opposed to monovalent ligands, which destabilise condensates. Even when they have no impact on condensate stability, bipartite ligands that bind to spacers and stickers can change the way scaffold molecules are arranged within condensates.

Committee Members
Speaker at Catalysis, Chemical Engineering & Technology 2025 - Stanislaw Dzwigaj

Stanislaw Dzwigaj

Sorbonne University, France
Speaker at Catalysis, Chemical Engineering & Technology 2025 - Thomas J Webster

Thomas J Webster

Interstellar Therapeutics, United States
Speaker at Catalysis, Chemical Engineering & Technology 2025 - Dai Yeun Jeong

Dai Yeun Jeong

Asia Climate Change Education Center, Korea, Republic of
Speaker at Catalysis, Chemical Engineering & Technology 2025 - Vladislav Sadykov

Vladislav Sadykov

Boreskov Institute of Catalysis, Russian Federation
CAT 2025 Speakers
Speaker at Catalysis, Chemical Engineering & Technology 2025 - Beatrice Vincenti

Beatrice Vincenti

Sapienza University of Rome, Italy
Speaker at Catalysis, Chemical Engineering & Technology 2025 - Haibo Ge

Haibo Ge

Texas Tech University, United States
Speaker at Catalysis, Chemical Engineering & Technology 2025 - Pengju Wu

Pengju Wu

School of Energy and Power Engineering Jiangsu University, China
Speaker at Catalysis, Chemical Engineering & Technology 2025 - Yaxin Su

Yaxin Su

Donghua University, China
Speaker at Catalysis, Chemical Engineering & Technology 2025 - Isabel Oller Alberola

Isabel Oller Alberola

Plataforma Solar de Almería, Spain
Speaker at Catalysis, Chemical Engineering & Technology 2025 - Majed Alamoudi

Majed Alamoudi

King Abdulaziz University, Saudi Arabia

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