Changing the concentrations of ligands—non-scaffold molecules that bind to particular sites on scaffolds—can control the phase transitions of scaffolds. The valence of ligands, whether or not they bind to spacers or stickers directly, and the relative affinities of ligand-scaffold versus scaffold-scaffold interactions all affect how modulatory an effect they have. The concentration of scaffolds in condensates is generally diluted by all ligands. Multivalent ligands have the ability to stabilise or destabilise condensates by directly binding to spacers or stickers, as opposed to monovalent ligands, which destabilise condensates. Even when they have no impact on condensate stability, bipartite ligands that bind to spacers and stickers can change the way scaffold molecules are arranged within condensates.
Stanislaw Dzwigaj
Sorbonne University, France
Thomas J Webster
Interstellar Therapeutics, United States
Dai Yeun Jeong
Asia Climate Change Education Center, Korea, Republic of
Vladislav Sadykov
Boreskov Institute of Catalysis, Russian Federation
Beatrice Vincenti
Sapienza University of Rome, Italy
Haibo Ge
Texas Tech University, United States
Pengju Wu
School of Energy and Power Engineering Jiangsu University, China
Yaxin Su
Donghua University, China
Isabel Oller Alberola
Plataforma Solar de Almería, Spain
Majed Alamoudi
King Abdulaziz University, Saudi ArabiaSubmit your abstract Today
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