Changing the concentrations of ligands—non-scaffold molecules that bind to particular sites on scaffolds—can control the phase transitions of scaffolds. The valence of ligands, whether or not they bind to spacers or stickers directly, and the relative affinities of ligand-scaffold versus scaffold-scaffold interactions all affect how modulatory an effect they have. The concentration of scaffolds in condensates is generally diluted by all ligands. Multivalent ligands have the ability to stabilise or destabilise condensates by directly binding to spacers or stickers, as opposed to monovalent ligands, which destabilise condensates. Even when they have no impact on condensate stability, bipartite ligands that bind to spacers and stickers can change the way scaffold molecules are arranged within condensates.
Stanislaw Dzwigaj
Sorbonne University, France
Dai Yeun Jeong
Asia Climate Change Education Center, Korea, Republic of
Enrico Paris
CREA-IT & DIAEE, Italy
Hanna Kierzkowska Pawlak
Lodz University of Technology, Poland
Ling Yin
Cornell University, United States
Tsitsishvili Vladimer
Petre Melikishvili Institute of Physical and Organic Chemistry at the Tbilisi State University, Georgia
Rafia Ahmad
King Abdullah University of Science and Technology, Saudi Arabia
Eun Han Lee
Korea Institute of Energy Research, Korea, Republic of
Neul Ha
Sungkyunkwan University, Korea, Republic of
Shailza Sharma
RMIT University, AustraliaSubmit your abstract Today
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