Carboxylation

By treating a substrate with carbon dioxide, a carboxylic acid is created in the process of carboxylation. Decarboxylation is the opposite process. When referring to the reaction of carbanionic reagents with CO2, the terms carbonation and carboxylation can be used interchangeably in chemistry. In a broader sense, carbonation often refers to the creation of carbonates. In organic chemistry, carboxylation is a common conversion. In particular, a traditional method for converting organic halides into carboxylic acids involves carbonation of Grignard reagents and organolithium compounds. Sodium phenolate, the sodium salt of phenol, is treated with carbon dioxide at high pressure (100 atm) and high temperature (390 K) in a process known as the Kolbe-Schmitt reaction to produce sodium salicylate, the precursor of aspirin. the resultant salicylate salt is acidified and gives salicylic acid.

Committee Members
Speaker at Catalysis & Reaction Engineering 2026 - Stanislaw Dzwigaj

Stanislaw Dzwigaj

Sorbonne University, France
Speaker at Catalysis & Reaction Engineering 2026 - Dai Yeun Jeong

Dai Yeun Jeong

Asia Climate Change Education Center, Korea, Republic of
Speaker at Catalysis & Reaction Engineering 2026 - Enrico Paris

Enrico Paris

CREA-IT & DIAEE, Italy
Speaker at Catalysis & Reaction Engineering 2026 - Hanna Kierzkowska Pawlak

Hanna Kierzkowska Pawlak

Lodz University of Technology, Poland
CAT 2026 Speakers
Speaker at Catalysis & Reaction Engineering 2026 - Ling Yin

Ling Yin

Cornell University, United States
Speaker at Catalysis & Reaction Engineering 2026 - Tsitsishvili Vladimer

Tsitsishvili Vladimer

Petre Melikishvili Institute of Physical and Organic Chemistry at the Tbilisi State University, Georgia
Speaker at Catalysis & Reaction Engineering 2026 - Rafia Ahmad

Rafia Ahmad

King Abdullah University of Science and Technology, Saudi Arabia
Speaker at Catalysis & Reaction Engineering 2026 - Eun Han Lee

Eun Han Lee

Korea Institute of Energy Research, Korea, Republic of
Speaker at Catalysis & Reaction Engineering 2026 - Neul Ha

Neul Ha

Sungkyunkwan University, Korea, Republic of
Speaker at Catalysis & Reaction Engineering 2026 - Shailza Sharma

Shailza Sharma

RMIT University, Australia

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