HYBRID EVENT: You can participate in person at Rome, Italy or Virtually from your home or work.
Renato Froidevauxa, Speaker at Chemical Engineering Conferences
Institut Charles Viollette – University of Lille, France
Title : From sequential chemo enzymatic approach to integrated hybrid catalysis: Concept and examples


Efficient and eco-responsible valorization routes for renewable carbon source are highly desirable, and every field of catalysis should be mobilized as the key to success for a selective valorization of such a polyfunctional substrate. Biocatalytic processes are already or about to be industrialized and heterogeneous or homogeneous catalysis, alone or in combination, have shown high efficiency for biomass valorization, but lack of selectivity still causes problems in the products separation steps. In the very last years, a new paradigm of catalysis has emerged to answer the challenges of selectivity and productivity by combining biocatalysis and chemocatalysis. Indeed, in a conventional approach, biotechnologies and chemocatalysis are sequentially processed. However, recently, successful one-pot transformations have been realized, simultaneously taking advantage of both technologies, under the concept of the so-called ‘hybrid catalysis’.

In this context, we propose two new conceptual pathways involving hybrid catalysis to overcome limitations resulting from the enzymatic glucose isomerase thermodynamic equilibrium between glucose and fructose, which is a key step when subsequently targeting HMF as a product. These concepts are based on a complexation/transport strategy and a hybrid isomerization, respectively. Both combinations are relatively simple to achieve and the first results validate the proof of concepts in both cases: (1) The limitations resulting from the enzymatic glucose isomerase thermodynamic equilibrium between glucose and fructose has been actually overcome with a glucose conversion of 70%, while it is limited to 46%, without fructose transport; (2) Concerning the valorisation via sorbitol, we demonstrated the chemical compatibility between sorbitol dehydrogenase and an organometallic complex used for the cofactor regeneration and ca. 2 cofactor regenerations by the chemocatalyst can be observed. However, the pH zones of the enzyme and the organometallic complex seems to be conflicting to enable reaching high yields. A modification of one of both catalysts could extend the pH zone toward the zone of the other catalyst.


He received his PhD degree in 2001 at the University of Lille. Now he is professor in Enzyme Engineering and Biotechnology at the same institution in the Charles Viollette Institute. He started his career in bioactive peptide production by enzymatic way and the development of reactors. From 2014, he works on the development of “hybrid catalysis” concept, resulting in the combination of bio- and chemo-catalysis.  He is leader of a team in Biotechnology/Biotransformation which is a constituent team of Viollette Institute. He has been coordinator of national projects on hybrid catalysis development (2015-2018 GENESYS; Program Research 2016-2018 with IFMAS). He is partner of BIOHEC project (European project Life+, 2016-2020) for biodiesel production from cooked oils. He is part of the user Committee of REALCAT platform. 6PhD already supervised, 4PhD ongoing, 4 postdoctoral already followed. He has published more than 35 publications in peer review journals, 2 book chapters, 1 patent.