Design and Development of New Efficient Routes for the Synthesis of Biologically Important Heterocycles via Catalytic C-C and C-heteroatom bond formation

Title : Design and Development of New Efficient Routes for the Synthesis of Biologically Important Heterocycles via Catalytic C-C and C-heteroatom bond formation

Abstract:

Small molecule heterocycles play important role in both drug discovery and material science research providing one of the richest source of diversity, besides serving as rigid scaffolds for further display of a range of functionalities. The present lecture will focuss on our recent research directed towards design and development of new, efficient and concise routes for biologically important heterocycles such as indoles, benzothiazoles benzothiophenes, benzofurans, substituted thiophenes, pyrazoles, imidazoles, oxazoles, bisoxazoles etc., involving transition metal catalyzed cross coupling and atom economy reactions such as C-H activation, domino reactions and multicomponent one-pot reactions, from easily accessibly organosulfur building blocks. Some of our recent results involving bio-inspired synthesis of few of non-natural indole alkaloids using β-carboline derived enaminone precursors will also be presented.

Audience take-away:

• The lecture covers simple one step methods for the synthesis of a broad range of biologically important heterocycles, such as indoles, benzothiophenes, benzofurans, pyrazoles, benzothiazoles thiophenes, oxazoles and imidazoles etc from easily accessible starting materials under mid conditions via transition metal catalysed or transition metal free C-Heteroatom bond formation. These methods can be extended for the synthesis of some important biologically important. heterocyclic targets, under simpler conditions. Definitely, the other faculty can expand their research by using these methods, besides including as part of teaching in heterocycle synthesis.

Biography:

Prof. Hiriyakkanavar Ila received her MSc from DAV College, Kanpur in 1964 and was the first woman to receive the PhD in 1968 from IIT Kanpur. She did postdoctoral work at Purdue University, Lafayette in 1969 and was Alexander von Humboldt Fellow at Ludwig Maximilian University, Munich (1984-85). She was a scientist at Medicinal Chemistry Division, CDRI, Lucknow (1970-76) and then moved to North Eastern Hill University, Shillong (1977) as a founding faculty member and continued for nearly 18 years. She moved to IIT Kanpur as Professor (1995) and continued till 2006. She was a Marie-Curie Visiting Fellow at University of Cambridge (1995) and a Visiting Professor at Locker Hydrocarbon Research Institute, USC, Los Angeles (2002), at Institut de Investigacuiones, Sovilla, Spain, and at Kuwait University (2007). She has published more than 285 research articles in SCI(E) journals.