Catalytic synthesis of Fluorinated Alkenes

Title : Catalytic synthesis of Fluorinated Alkenes

Abstract:

Thanks to the unique properties of the fluorine atom, the fluorinated compounds are of great interest in many key fields such as pharmaceutical, agrochemical or materials science. Among the organofluorinated molecules, the fluoroalkenes are recognized as a pivotal class of compounds towards the synthesis of materials, bioactive compounds or ¹⁹F NMR labeling, for example. The fluoroalkene moiety is also recognized as a stable isosteric and isoelectronic mimic of the amide bond. So, it can therefore be used as a bioisostere in structure− activity relationship studies in pharmaceutical or agrochemical domains or to overcome problems associated with the instability of peptides. Some fluorinated alkenes building blocks can also serve as platform for further transformation by radical chemistry or conjugated addition. Among the various methods reported to synthesize fluoroalkenes, we have developed several catalytic accesses to these molecules including CH-functionnalization, cross-coupling reaction or metathesis. In this presentation I will focus on our recent catalytic developments in Mizoroki-Heck and metathesis reaction regarding the synthesis of fluorinated alkenes. Some applications of these compounds will also be discussed.

Audience take-away:

• The audience will learn about the fluorine chemistry and more specifically about the fluoroalkenes syntheses and their various applications. They will also learn a bit about the catalytic reactions presented.
• I am not sure it will help the audience in their job but definitively, if people have to work on fluorinated alkenes or compounds, it could help.

Biography:

Samuel Couve-Bonnaire received his Ph.D. in 2001 under the supervision of Pr. Y. Castanet and J.-F. Carpentier at the Laboratory of Catalysis of Lille, homogeneous section directed by the Pr. A. Mortreux. Then he carried out his postdoctoral studies in Canada in the laboratory of Pr. Prabhat Arya at the Steacie Institute for Molecular Sciences, Ottawa, National Research Council Canada. Back to France, he was post-doctoral researcher with Sanofi-Aventis as industrial partner. Since February 2005, he is working as an associate professor in the group of “fluorinated biomomecules synthesis”, in COBRA laboratory and published more than 60 research articles in SCI(E) journals