Bio-catalytic Approach to Synthesis of Modified Nucleosides

Title : Bio-catalytic Approach to Synthesis of Modified Nucleosides

Abstract:

Over two decades, a large number of nucleosides have been synthesized, which demonstrated potent antiviral and antitumour activities and have become cornerstones of treatment for patients with cancer or viral infections. Oligonucleotide-based antisense strategies represent a unique paradigm for the treatment of a wide variety of human diseases. In order to discover new class of nucleoside derivatives with enhanced biological activities, the modifications in the sugar moietiy have been attempted, which provide a remarkable level of control over nucleoside sugar puckering and its biological activity.

Herein, we report; (a) the selective biocatalytic acetylation studies on modified 3′-azido-4′-C-hydroxymethylated sugar derivatives with an aim to develop an efficient and easy method for the synthesis of ribo-azido/amino LNA monomers and xylo-azido/amino spiro-oxetano nucleosides and (b) the selective biocatalytic deacetylation studies on modified 3′-azido-4′-C-acetoxymethylated sugar derivatives with an aim to develop an efficient and easy method for the synthesis of ribo-azido/amino spiro-oxetano nucleosides and xylo-azido/amino LNA monomers.

Biography:

Dr. Rajesh Kumar is currently working as an Assistant Professor at the P.G. Department of Chemistry, Ramdayalu Singh College, B.R.A. Bihar University, Muzaffarpur, India. Dr. Kumar has obtained his master’s degree and pursued his doctoral research from the Department of Chemistry, University of Delhi, Delhi. His doctoral research focused on synthesised of modiafied nucleosides and their therapeutic applications. Dr. Kumar visited University of Southern Denmark, Denmark. During master’s degree, he has qualified CSIR-JRF and Gate. He has published more than 40 publications in reputed international journal such as Journal of Organic Chemistry, European polymer journal, Theranostics etc.  He has participated and delivered invited lecture in various international and national conferences in India and abroad (USA, Japan, Spain). His research interest lies in Metal complexes, Biotransformations, Catalysis, Green Chemistry, Nucleoside and Heterocyclic Chemistry.