Ferrocene-based unsymmetrical bis phosphines, Fc (PAd2)(PR2) (R= Ph, Cy, iPr and tBu) abbreviated as MPhos ligands, as well as their corresponding (MPhos)PdCl2 complexes as pre-catalysts were developed in very good yields and fully characterized. These complexes as precatalysts were effectively utilized for many Csp2-Csp3 cross-coupling reactions such as Murahashi-Feringa, Kumada-Corriu, Negishi and Suzuki-Miyaura for model and “drug-like” substrates to demonstrate their potential applications in API synthesis. The details of the design of the catalysts and their applications in organic synthesis will be presented.
Audience Take Away:
- They can understand the latest development in cross coupling the most active area in homogenous catalysis.
- Apply the principles in organic synthesis for pharmaceutical, electronics and agrochemicals applications both in academia and industry.
- Yes, of course. Sp2-sp3 coupling one of the underdeveloped areas in cross coupling
- Will it improve the accuracy of a design, or provide new information to assist in a design problem? Yes.
- These catluarts are now commercially available through MilliporeSigma (Merck KGaA, Darmstadt, Germany)
Thomas J. Colacot joined MilliporeSigma (a business of Merck KGaA, Darmstadt, Germany) in 2018 as an R&D Fellow and Director of Global Technology Innovation, Life Science Business, in Milwaukee, WI. He has extensive experience in developing new and innovative products and technology with a very strong track record of commercialization globally and is considered an industrial expert in organometallics and homogeneous catalysis in organic synthesis. He has over 120 peer-reviewed publications and over 65 patents internationally. Thomas is a recipient of many awards and honors, including the 2021 Scientific Curriculum Vitae (Life Time Achievement Award) from the Chairman of the Board and CEO of Merck KGaA, Darmstadt, Germany; the 2018 Outstanding Researcher Award from Merck KGaA, Darmstadt, Germany; the 2017 Catalysis Club of Philadelphia Award for outstanding contributions in the area of catalysis; the 2015 ACS Industrial Chemistry Award; the 2015 IPMI Henry Alfred Award; the 2016 IIT Madras Distinguished Alumnus Award for Technology Innovation; the 2016 Chemical Research Society of India (CRSI) Medal; and the 2012 RSC Applied Catalysis Award and Medal. Dr. Colacot was responsible for developing a very successful homogeneous catalysis program at Johnson Matthey from 1995 to 2018. He holds an MBA degree from Penn State University and a Ph.D. degree in chemistry from IIT Madras. He has also carried out postdoctoral work in the U.S. and is a fellow of the Royal Society of Chemistry. He is also a visiting professor many leading universities internationally.