Title : Visible Light in Heterocyclic Chemistry: An efficient and Environmentally Friendly Protocol for the Synthesis Polyfunctionalized Substituted Cinnolines
Visible light has evolved into a widely used for many types of transformations in organic synthesis. Cinnolines are interesting classes of heterocycles owing to their strong pharmaceutical and medicinal activities. In the current study, we developed a simple and efficient synthesis of polyfunctionalized substituted cinnoline derivatives (3) that relied on reaction of ethyl 5-cyano-4-methyl-1-aryl-6-oxo-1,6-dihydropyridazine-3-carboxylates with nitrostyrene in visible light (White LED, 30 W) and catalysed by piperidine with ethanol as a solvent. This method seems to be green, simple and with high atom economy.
- This work provides a facile method for the synthesis of bioactive cinnolines.
- It will encourage synthetic chemists to use visible light as an alternative approach.
- It will contribute to the idea of making chemistry greener.