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Jaeyoung B, Speaker at Chemical Engineering Conferences
Hanyang university, Korea, Republic of
Title : Copper(I)-catalyzed synthesis of 1,2,3-Triazoles from azidoformates, electron-deficient azides


Since the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction was discovered, which is one of the classical click reactions, a various range of the 1,2,3-Triazole synthesis has been extensively developed. In case of formation of 1,2,3-triazole with electron-deficient azides such as N-sulfonyl , carbonyl, and cabamoyl, only a few system have been reported. We have first found the formation of regioselective 1,4-disubstituted 1,2,3-triazoles from terminal alkynes and azidoformates, which are electron-deficient azide groups,  using commercialized [(CH3CN)4Cu]PF6 copper catalyst with mild condition. This methodology can be applied to the synthesis of various bioactive triazole derivatives with other electron-deficient groups.


She was received the Bachelor’s degree in Applied Chemistry from Hanyang University in 2016. Now, she is studying organometallic chemistry for Master’s degree in the group of prof. Hakjune Rhee at Hanyang University. Her interest is the development of organic synthesis using various metal catalysts.