Title : Transferase enzymes used in drug synthesis
Abstract:
Transferase enzymes catalyse the transfer of different functional groups of a donor molecule to another molecule. In drug synthesis, they are especially used to obtain enantiomerically pure drug intermediates. This kind of chemoenzymatic synthesis is used to improve unfavourable conditions of traditional chemical syntheses. Unlikely chemical syntheses, chemoenzymatic syntheses are more efficient, faster, more affordable, more effective, and environmentally friendly. For this purpose, the number of studies of researchers about chemoenzymatic syntheses is increasing day by day.
In this presentation about transferase enzymes that are obtained from various sources to be used in chemoenzymatic syntheses were evaluated. Glycosyltransferase and transaminase enzymes are investigated in detail. Glycosyltransferase enzymes were used to obtain derivatives of vancomycin which is an antibiotic. Transaminase enzymes were used in the synthesis of rivastigmine which is a drug used in the treatment of Alzheimer's disease, steroid, and steroid derivatives, levetiracetam which is an anticonvulsant drug, sitagliptin which is an antidiabetic medication and glasdegib which is an inhibitor of SMO (Smoothened). Studies in the literature have been examined in detail in terms of parameters such as general properties of used enzymes, reaction medium, the yield obtained as a result of synthesis, conversion, and enantiomeric excess rates in these studies.
